Similar gene expression levels of HIF-1α and CREB were observed between the tumor cell lines (HT29 and B16F10 cells) and normal cell lines (HUVECs and HEK293 and Balb3T3 cells), but HT29 cells had higher expression levels of NF-κB than HEK293 cells and HUVECs (Fig. 5a). The gene discussed is CREB1; the disease is neoplasm.