These findings might have a significant role in relation to diesel and PM carcinogenic potency, since deregulation of EREG is known to contribute to the progression of different cancers, including lung, and to lead to an aggressive phenotype and an unfavorable prognosis in KRAS-mutant non-small-cell lung carcinoma (NSCLC) [62, 64],. This evidence concerns the gene EREG and non-small cell lung carcinoma.