LOX-1 is a 52-kDa surface receptor that is a type II membrane protein belonging to the C-type lectin family.[22] LOX-1 is an ox-LDL receptor in ECs.[11] In normal conditions, the expression of LOX-1 is very low; however, in pathological conditions such as hypertension, diabetes, myocardial ischemia, hyperlipidemia, ischemic reperfusion injury, transplantation, and atherosclerosis, LOX-1 expression is upregulated.[23] Previous literature supports the presence of an association between LOX-1 and ISR. The gene discussed is OLR1; the disease is diabetes mellitus.