LMNA and familial dilated cardiomyopathy: Since LMNA gene mutations are causally involved in patients with idiopathic dilated cardiomyopathy (3.6%) and familial dilated cardiomyopathy (7.5%) [27], we hypothesized that accumulation of progerin in non HGPS ́s individuals in the heart may as well be involved in the progression of DCM.