As shown in Fig 3A, RT-PCR analyses of samples from DCM hearts (n = 15) revealed a significant upregulation of progerin mRNA as compared to non-failing controls (n = 10) (1.27 ± 0.42 vs. 0.81 ± 0.24; p = 0.005). This evidence concerns the gene LMNA and familial dilated cardiomyopathy.