IGF1R and colorectal carcinoma: Although miR-7 has largely been reported as oncogenic, a recent study showed that circHIPK3 promoted CRC growth and metastasis by inhibiting miR-7 and upregulating its targeted proto-oncogenes FAK (focal adhesion kinase), IGF1R, EFGR and YY1 (Yin Yang 1 transcription factor) [159]