PTEN and lung carcinoma: Through its interaction with miR-21 and miR-222, GAS5 upregulates PTEN to activate the PTEN/AKT (AKT serine/threonine kinase 1/protein kinase B) pathway, and suppresses growth in thyroid, gastric, endometrial, cervical, and lung cancers [63,64,65,66,67].