Collectively, CDR1as upregulates CCNE1 (cyclin E1) and PIK3CD (phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta) in HCC, EGFR and IGF1R in CRC, RELA (RELA proto-oncogene, NF-κB subunit) in NSCLC, and activates the PI3K/AKT pathway in gastric cancer to promote cell proliferation, migration and invasion [151,152,153,154]. The gene discussed is PIK3CD; the disease is hepatocellular carcinoma.