HOXD-AS1 modulates the miR-130a/E2F8 (E2F transcription factor 8) axis in glioma, the miR-130a-3p/SOX4 (SRY-box 4) axis in liver cancer, and the miR-608/FZD4 (frizzled class receptor 4) axis in ovarian cancer [119,120,121]. This evidence concerns the gene FZD4 and central nervous system cancer.