Through miR-186-5p, PVT1 modulated the expression of YAP1 (Yes associated protein 1) and HIF-1α (hypoxia-inducible factor 1-alpha) to effect invasion and migration in HCC and gastric cancer; ATG7 (autophagy related 7) and BECN1 (beclin 1) to induce protective autophagy and angiogenesis in glioma; and TWIST1 to promote EMT in prostate cancer [102,103,104,105]. Here, BECN1 is linked to Familial prostate cancer.