Then, rSVIGF1 therapeutic efficacy was studied in rats, in which liver cirrhosis was induced by carbon tetrachloride (CCl4) inhalation and showed that the hepatic levels of IGF1 and IGFBP3 were higher in rSVIGF1-treated rats than in control cirrhotic animals. This evidence concerns the gene IGFBP3 and cirrhosis of liver.