MAPT and major depressive disorder: Similarly, we also found the Geriatric Depression Scale (HR: 1.175, CI: 1.007–1.372, Wald: 4.189, P = 0.041) and amyloid-β:tau (HR: 78.317, CI: 2.501–2452.692, Wald: 6.158, P = 0.013) to be predictors of cognitive impairment.