Indeed, overexpression of this lncRNA is associated with the activation of EMT in numerous cancers, including pancreatic cancer, CRC, nasopharyngeal carcinoma, bladder cancer, gallbladder cancer, and oesophageal cancer4 [21], where it has been shown to silence E-cadherin through recruitment of EZH2 to its promoter, or functions as a ceRNA for several pro-EMT miRNAs [21]. The gene discussed is EZH2; the disease is colorectal carcinoma.