In renal cell carcinoma, a link between MALAT-1 and c-MYC, a downstream effector of Wnt/β-Catenin signalling, was found to be an element in the regulation of β-catenin and transcription factor c-Myc [116]; other lncRNAs have now been shown to play additional roles in regulating EMT via either c-Myc or n-Myc. This evidence concerns the gene MYCN and hereditary clear cell renal cell carcinoma.