PDCD1 and non-small cell lung carcinoma: Additionally, Tremelimumab, a noncomplement fixing IgG2 antibody, has been tested alone or in combination with other antibodies such as Durvalumab (a PD-1 inhibitor) and improves antitumor activity in patients with non-small cell lung cancer (NSCLC), melanoma, colon cancer, gastric cancer, and mesothelioma treatment [69,70,71,72,73,74].