TGFB1 and cancer: Focus on the cytokine TGF-β in the context of fibrosis and cancer progression is very useful; this is because the elucidation of mechanisms that regulate TGF-β ligand deposition and activation in the ECM, signalling receptors and intracellular mediators and expression of target genes of this pathway offer a truly integrative perspective in analysing communications and reactions between all cell types that participate in the progression of these pathologies in every human organ.