In a transgenic K‐Ras knock‐in mouse pancreatic ductal adenocarcinoma (PDAC) model with NRF2 simultaneously deleted, pancreatic intraepithelial neoplasia (PanIN), cell proliferation and the tumour burden were reduced.21 NRF2 also sustains metabolic reprogramming in cancerous cells. The gene discussed is NFE2L2; the disease is pancreatic ductal adenocarcinoma.