LRRK2 and Parkinson disease: As illustrated in Table 2, twelve loci showed genome-wide significant association (ORs ≥ 1.1; p values < 5 × 10−8) with PD risk from case–control genotype data in 4 or more independent samples: SNCA, TMEM175, STK39, TMEM229B, LRRK2, BCKDK, MIR4697, INPP5F, RIT2, GCH1, SIPA1L2, TMPRSS9 (Lill et al. 2012).