HTRA2 and Parkinson disease: However, evidence for the pathogenesis of HTRA2/OMI in PD has been further supported by whole exome sequence analyses in patients with PD from the Taiwan, Pakistan, Mexico, and in affected infants, born of consanguineous parents of Druze and Ashkenazi origins (Lin et al. 2011; Mandel et al. 2016; Oláhová et al. 2017).