Clinically, patients affected with DJ-1 mutations were found to have an early asymmetric development of dyskinesia, hyperreflexia, rigidity, and tremor, with later psychiatric symptoms including, psychotic disturbance, cognitive decline (uncommon), anxiety, and also a good response to l-DOPA (similar to clinical and phenotypic features of patients with PARKIN and PINK1 mutations) (Abou-Sleiman et al. 2003; Annesi et al. 2005; Bonifati et al. 2003; Ibáñez et al. 2006). This evidence concerns the gene PRKN and drug-induced dyskinesia.