However, there is some controversy surrounding the role of GIGYF2 gene in the pathogenesis of PD, since several recent studies did not provide strong evidence for the association between GIGYF2 gene mutations and PD (Bras et al. 2008; Di Fonzo et al. 2009b; Guo et al. 2009). Here, GIGYF2 is linked to Parkinson disease.