LRRK2 and Parkinson disease: Mutation in Leucine-rich repeat kinase2 (LRRK2) gene is known as one of the common genetic cause of PD (Healy et al. 2008); they are responsible for at least 4% of autosomal dominant forms of familial PD typically associated with late onset and are also found in 1% of sporadic PD worldwide (Di Fonzo et al. 2005; Gilks et al. 2005; Nichols et al. 2005).