Among them, 14 genes were associated with the poor survival of ccRCC patients (Supplementary Fig. S1a), namely, TGFB1, LAMA5, PTHLH, FOXM1, TIMP1, CAV1, CDKN2A, ITGA5, CTSZ, LOX, PLAUR, MMP9, LOXL2 and FSCN1; the other 9 genes were related to a better prognosis (Supplementary Fig. S1c). The gene discussed is LOXL2; the disease is nonpapillary renal cell carcinoma.