ICOS and nonpapillary renal cell carcinoma: To identify the potential therapeutic targets of EMT and immune escape, 15 representative emerging immune checkpoint genes were selected according to a previous report11 and the correlation coefficient in this ccRCC model: IL10, CD4, TNFSF4, PDL2, IL6, PDL1, LAG3, CTLA4, ICOS, TIM3, ICOSLG, OX40, CXCR4, TGFB1, and B7H3 (CD276).