Although staining of E-cadherin was performed centrally, we had lower than expected percentages of E-cadherin associated lobular breast cancers, which may reflect variation in calling of histologic subtypes, but could also indicate the need for molecular profiling methods or more detailed image analysis studies on the compartment of where E-cadherin is stained needed, for defining E-cadherin loss47,48. Here, CDH1 is linked to Hereditary breast cancer.