This model is further supported by our finding that EPHB6 increases killing of tumoursphere cells by therapeutic compounds that depend on high rates of cell proliferation, such as doxorubicin or docetaxel, while not improving elimination of cancer cells in monolayers, where EPHB6 has no significant effect on cell propagation [47] (Supplementary Figure S6A and B). This evidence concerns the gene EPHB6 and cancer.