KDM4A and colorectal cancer: We found that JIB-04 up-regulated the di-methylation and tri-methylation of H3K9 as well as the tri-methylation of H3K36 in HCT116, HT29, and DLD-1 cells, suggesting that JIB-04 inhibits the JMJD2 histone demethylase family in colorectal cancer cells (Fig. 7D).