Consistent with our own directed sequencing studies, perusal of recent MPN70,71, acute erythroleukemia (250 samples total in two studies72,73), and AML tabulations74, along with those derived from The Cancer Genome Atlas (TCGA) data sets75,76 do not reveal a role for KLF1 in any case in these blood cancers. Here, KLF1 is linked to hematopoietic and lymphoid system neoplasm.