To determine the role of YAP1 in the development of NSCLC, we first examined YAP1 expression in 14 tumor samples by immunohistochemistry (IHC) assays; we found that YAP1 expression was obviously higher in NSCLC tissues than in paired adjacent tissues (Fig. 1a). The gene discussed is YAP1; the disease is non-small cell lung carcinoma.