Further, the relationship between altered dynamics protein levels and sensitivity to SMAC mimetics was not a unique feature of TYKNU cells or HGSOCs, as knockout of OPA1 or DNM1L similarly potentiated the toxicity of SMAC mimetics in cell lines derived from non-high-grade ovarian carcinoma (MCAS and TOV-112), lung adenocarcinoma (PC9), melanoma (A375), breast cancer (T47D), and pancreatic cancer (Panc03.27) (Fig. 3c–f and Supplementary Fig. 3b, c). Here, OPA1 is linked to familial pancreatic carcinoma.