OPA1 and familial pancreatic carcinoma: Using publicly available datasets from The Cancer Genome Atlas (TCGA), we found that four of these genes—OPA1, MFN1, FIS1, and DNM1L—are recurrently amplified in certain cancers at frequencies exceeding 5%: HGSOC, breast cancer, head and neck squamous cell carcinoma (HNSCC), pancreatic cancer, and lung cancer (using a pan-analysis of lung adenocarcinomas and lung squamous cell carcinomas) (Fig. 1a)19,20,23–26.