We focused on genes related to Th2 response, and found that the Rad50 HS 5 (RHS V) within the Th2 cytokine LCR had significantly reduced accessibility in Bcl11b-deficient T-helper cells compared to WT cells from asthma-induced mice (Fig. 6d), despite the fact that Bcl11b did not bind to this region (Fig. 5c). The gene discussed is BCL11B; the disease is asthma.