To establish the mechanisms associated with reduced Th2 response in asthmatic and helminth-infected Bcl11bfl/fl dLck-iCre mice, we next performed RNA-sequencing on CD4+ T-cells isolated from: (1) mediLNs of asthma-induced Bcl11bfl/fl dLck-iCre and WT mice, and (2) mLNs of helminth-infected mice, and found that a large number of mRNAs significantly changed (Supplementary Figure 3). Here, CD4 is linked to asthma.