Expression of the major component in the Wnt pathway (glycogen synthase kinase-3β [GSK3β]) and downstream effectors of the Wnt pathway (β-catenin, Cyclin D1, c-Myc, and Survivin) was assessed by western blot in lung cancer cells in which HOXA4 had been overexpressed or knocked down. The gene discussed is BIRC5; the disease is lung carcinoma.