These data suggested a coherent mechanism for the role of 1700020I14Rik in cell proliferation and fibrosis during DN, and provided new insights into the mechanisms of renoprotection associated with1700020I14Rik and miR-34a-5p/Sirt1/HIF-1α, which could lead to a novel therapeutic strategy for DN. Here, HIF1A is linked to liver dysplastic nodule.