SMAD7 and infection: Consistent with this, and in contrast to the effects of infection with Ad-Smad7, HFD-fed mice infected with Ad-Smads2/3/4 exhibited lower lipogenesis (Fig. 6a), liver triglyceride (Fig. 6a), circulating total cholesterol, high-density lipoprotein (HDL)-cholesterol, and low-density lipoprotein (LDL)-cholesterol (Fig. 6b).