KLF12 and neoplasm: For example, FLF12 promoted gastric cancer cell proliferation and invasion in vitro [21], and recent research showed that KLF12 enhancement was found in approximately 40% of esophageal adenocarcinoma cancers [22] and in 45% of salivary tumors [23] and our results demonstrate that KLF12 acts as a tumor-suppressor and chemical sensitizer in CRC and this involved with miR-382, miR-382 overexpression induce KLF12 significantly decreased.