While, there was no change in phospho-ERK1/2 expression in the synaptoneurosomes of MS animals when compared with littermate Ctrl pups (Figure 3A); we observed an appreciable reduction in phospho-Akt (pThr308 and pSer473 forms; Figure 3B,C) in the hippocampal synaptoneurosomes isolated from MS animals. The gene discussed is AKT1; the disease is myeloid sarcoma.