Patients with heterozygous truncation mutations or deletion of DYRK1A share a phenotype with microcephaly, intellectual disability, language delay, epileptic seizures, neonatal feeding problems, and facial dysmorphism (Møller et al., 2008; Courcet et al., 2012; Ji et al., 2015; van Bon et al., 2011; Redin et al., 2014; Ruaud et al., 2015; Luco et al., 2016). Here, DYRK1A is linked to microcephaly.