For example, EpCAM-CD98hc-CD147 complex can regulate the Akt/mTOR/AMPK signaling through stablizing the amino acid transporter LAT1 and changing the susceptibility of PCa stem-like cells to EGF, and finally promote the adaption to hypo-nutrient condition [27, 28]. This evidence concerns the gene AKT1 and posterior cortical atrophy.