Down-regulation of CR by CALB2 shRNA in human MM cell lines profoundly decreases cell growth and viability in vitro: lentivirus-mediated delivery of shCALB2 causes MM cells, in particular the ones with an epithelioid morphology, to enter apoptosis within 72 h post-infection [3]. The gene discussed is CALB2; the disease is Miyoshi myopathy.