It is highly likely that proteins responsible for renal calcium transport, including the epithelial calcium channel (TRPV5), calbindin-D28K, the Na/Ca exchanger (NCX1) and plasma membrane Ca-ATPase (PMCA), may be altered in hypertensive disease thus justifying and explaining the reported hypercalciuria. The gene discussed is TRPV5; the disease is hypertensive disorder.