IGHE and infection: Lower IFN-α and IFN-β scores at day 4 were associated with greater reductions in FEV1 (r = 0.54 and 0.51, P = .014 and .029; Fig 2, K and L) during infection and also correlated with higher levels of total baseline serum IgE (r = −0.58, P = .007 and r = −0.50, P = .02; Fig 2, M and N).