Similarly, greater numbers of subepithelial TLR3+ cells during infection were associated with worse rhinovirus-induced AHR (lower day 6 histamine PC10 values; r = −0.51, P = .014; Fig 5, C) and reductions in FEV1 (r = −0.44, P = .034; Fig 5, D), as were numbers of RIG-I+ cells (r = −0.68, P = .001; Fig 5, E). Here, RIGI is linked to infection.