In contrast, the Tf‐D‐LP4 and R‐Tf‐D‐LP4 peptides are targeted to cancer cells overexpressing TfR and thus specifically disrupt the HK‐VDAC1 interaction in cancer cells and affect overall cellular bioenergetics, as well as activating apoptosis (Figs 4, 5 and S2). Here, TFRC is linked to cancer.