Previous DIO studies on the DA system have focused on ex vivo striatal slice preparations and/or in vivo measurements in a single brain area, and, further, the majority have employed a prolonged HF or other high caloric diet of 4-weeks or longer and consistently reported decreased DA D2R [1,2,4] and reduced DAT function [8,33–36]. The gene discussed is SLC6A3; the disease is hydrops fetalis.