A thin corpus callosum is also found in other forms of HSP, including SPG1, SPG7, SPG11, SPG18, SPG21, SPG32, SPG45, SPG46, SPG47, SPG48, SPG49, SPG52, SPG54, SPG56, SPG63, SPG65 and SPG71 [1, 3]. Here, CYP2U1 is linked to hereditary spastic paraplegia.