Therefore, we examined NF-κB activation by analyzing the phosphorylation of IκBα and NF-κB DNA binding in KSHV-associated PEL cell lines after shRNA-mediated knockdown of CADM1, as well as NF-κB target gene induction in either vFLIP or vGPCR-expressing Cadm1−/− MEFs and wild-type MEFs. Here, CADM1 is linked to primary effusion lymphoma.