According to the role of complex gangliosides, especially GD2, in breast cancer cells EMT and aggressiveness, the increased expression of GD2 in breast cancer cells under TNF treatment could establish a link between the presence of pro-inflammatory cytokines at the tumor site environment, expression of complex gangliosides and EMT, resulting in more aggressive cells with increased tumorigenicity and increased resistance to treatment. This evidence concerns the gene TNF and breast carcinoma.