Given the critical role of both GD2 ganglioside and inflammation in breast cancer aggressiveness [21], and in order to provide a general overview of the effect of inflammatory cytokines on ganglioside biosynthesis, we examined the effect of TNF on the expression of the main ganglioside-specific GT genes as well as cell surface gangliosides in breast cancer cells from different molecular subtypes. This evidence concerns the gene TNF and breast carcinoma.