SH2B3 and colorectal cancer: For example, using colorectal cancer and endometrial cancer genome-wide data for ~13,000 cases unselected for age of disease onset or family history, and ~40,000 controls, Cheng and colleagues identified two novel polymorphisms, rs3184504 in the SH2B3 gene and rs12970291 near the TSHZ1 gene with evidence for a shared colorectal and endometrial cancer predisposition [39].