Daley et al., using a sib-pair analysis of a genome-wide linkage scan of 33 families with a breast-colorectal cancer phenotype, detected multiple linkage peaks, one of them in the region of BRCA2. They also detected other novel linked regions, including D17S1308 on chromosome 17p, in close proximity to the candidate gene hypermethylated in cancer 1 gene, HIC1 [13]. Here, BRCA2 is linked to colorectal cancer.