Among studies investigating NLR and PLR in brucellosis, Olt et al. (32) reported that adult patients with brucellosis had significantly increased Hb and NLR, while Aktar et al. (31) reported that NLR and PLR were direct indicators of inflammation in children with Brucella-arthritis and Bozdemir et al. (34) found significantly altered Hb and NLR in children with brucellosis. This evidence concerns the gene GSTM1 and arthritic joint disease.