When applying this technique to V. vulnificus, a dangerous septicaemic pathogen, we have been able to describe new genes involved in protection against human complement from new CPS biosynthetic genes to genes for hypothetical proteins as well as genes with a putative role in overcoming heat-resistant constraints in serum such as genes for OMPs (OmpH and others), biosynthetic/modifying LPS enzymes, a NQR system, a T2SS, and biosynthetic nucleotide enzymes, all of them supposedly essential to grow in serum and to allow the pathogen to proliferate in blood and cause death by septicemia. This evidence concerns the gene CAD and Sepsis.