This is noteworthy since, under physiological conditions, sCD137 is generated by proteolytic cleavage from the cell surface of activated lymphocytes.38, 39 An upregulated specific MMP, i.e., gelatinase B and MMP‐9, which could cause the cleavage of CD137 from the cell surface during the acute stage of stroke,40, 41 may contribute to the increased release of sCD137. The gene discussed is TNFRSF9; the disease is Stroke.