With correction of the genetic effects, per 10 ng/mL increase of corrected AFP levels could significantly increase 434% HCC risk compared to that per 10 ng/mL increase of AFP levels only increase 404% HCC risk (OR = 5.34, 95% CI = 2.57–11.13; P < 0.001 vs. OR = 5.04, 95% CI = 2.46–10.30; P < 0.001), in the fully adjusted logistic regression model. The gene discussed is AFP; the disease is hepatocellular carcinoma.