LMNB1 and adult-onset autosomal dominant demyelinating leukodystrophy: Thus, heterozygous mutations in LMNB2 have been reported to predispose to the development of acquired partial lipodystrophy (APLD), also called “Barraquer‐Simons syndrome” (Hegele et al., 2006), and duplication of LMNB1 leads to adult‐onset autosomal‐dominant leukodystrophy (ADLD; Padiath et al., 2006).