RTN4R and Brain atrophy: The HI injury caused severely brain atrophy, marked by a decrease in the right-to-left hemispheric weight ratio in HI group(0.35 ± 0.20, p < 0.001 vs. the sham group), but the brain atrophy was significantly improved in the HI + NGR1 group (0.64 ± 0.18, p < 0.01 vs. the HI group) (Fig. 2f).