Although several previous studies have provided the evidence of the possibility of sustained “biologic-free remission” with no functional or radiographic progression in patients with early RA after treatment with combination of TNF inhibitors and MTX [8], [9], [10], [19], [20], [21], [22], [23], the efficacy results are less convincing for established patients with RA who have inadequate responses to MTX. Here, TNF is linked to rheumatoid arthritis.