EGFR and non-small cell lung carcinoma: In a phase II trial in 154 Asian EGFR-mutant NSCLC patients, the addition of bevacizumab to erlotinib as first-line treatment significantly improved PFS compared to erlotinib alone (16.0 vs. 9.7 months, HR 0.54; 95% CI: 0.36–0.79, p = 0.0015) (61), leading to EMA approval of the combination in this population in April 2016.