In a retrospective multi-institutional analysis in 351 EGFR-mutant TKI-naïve NSCLC patients with BM, median OS for three alternative strategies, SRS followed by an EGFR TKI (n = 100), WBRT followed by an EGFR TKI (n = 120), or an upfront EGFR TKI (n = 131), was 46, 30, and 25 months, respectively (p < 0.001) (124). Here, EGFR is linked to non-small cell lung carcinoma.