The ASCEND-8 (NCT02299505) aimed to evaluate whether administering ceritinib, 450 or 600 mg, with a low-fat meal may enhance gastrointestinal tolerability vs. 750 mg fasted while maintaining similar exposure in 267 treatment-naive ALK-positive NSCLC (neurologically stable BM were stable). Here, ALK is linked to non-small cell lung carcinoma.