EGFR and non-small cell lung carcinoma: In the AURA3 trial, osimertinib demonstrated significantly greater efficacy in RR (71 vs. 31%) and PFS (10.1 vs. 4.4, HR 0.30, 95% CI: 0.23–0.41, p < 0.001) than platinum-pemetrexed chemotherapy, in 419 T790M-positive NSCLC patients who had progressed on first-line EGFR TKIs (47).