EGFR and non-small cell lung carcinoma: In a combined dataset post hoc analysis in 81 EGFR-mutant NSCLC patients with BM (30% had received brain radiotherapy) in the first-line LUX-Lung 3 and LUX-Lung 6 phase III clinical trials, afatinib significantly improved PFS (8.2 vs. 5.4 months, hazard ratio (HR) 0.50, p = 0.0297) and RR (21 vs. 5%, p = 0.0027), although without a significant difference in OS (22.4 vs. 25.0 months; HR 1.14, p = 0.64) compared with platinum-based chemotherapy (37).