The combination of the BRAF inhibitor dabrafenib with the MEK inhibitor trametinib was approved by the FDA and EMA based on clinical activity in 57 pretreated BRAF-V600E-mutated NSCLC patients (1–2% of lung adenocarcinoma patients) following a phase II trial giving an RR of 67% and median PFS and OS of 8.6 and 18.2 months, respectively, however no data regarding CNS efficacy are available (117). The gene discussed is BRAF; the disease is lung adenocarcinoma.