TNFSF10 and colorectal cancer: Exosomes induction of apoptosis in activated CD8+ T cells was reported by Wieckowski and colleagues (54), and immunosuppression mediated by human colorectal cancer (CRC) cells’ exosomes, bearing both FasL and TNF-related apoptosis-inducing ligand (TRAIL), was demonstrated, also acting through the induction of apoptosis of activated human T lymphocytes (Figure 3) (58).