TGFB1 and neoplasm: Furthermore, phenotypic changes were also reported, namely an increase in the expression of immunosuppressive cytokines and cytotoxins, such as CTLA-4, FasL, TGF-β1, granzyme B, perforin, and IL-10 in the cells co-cultured with the tumor-derived exosomes, but not in the ones in contact with DC-derived exosomes (55).