Previously, Mirtschink et al. have demonstrated that myocardial hypoxia activates fructose metabolism via HIF-1α-SF3B1-KHK-C axis in human and mice models of pathological cardiac hypertrophy (Mirtschink et al., 2015) underlying the importance of fructose metabolism in the regulation of cardiomyocyte growth in adults. The gene discussed is SF3B1; the disease is cardiac hypertrophy.