HIF1A and cardiac hypertrophy: Previously, Mirtschink et al. have demonstrated that myocardial hypoxia activates fructose metabolism via HIF-1α-SF3B1-KHK-C axis in human and mice models of pathological cardiac hypertrophy (Mirtschink et al., 2015) underlying the importance of fructose metabolism in the regulation of cardiomyocyte growth in adults.