Interestingly, MCT4 expression is induced by hypoxia (Mirtschink et al., 2015) and upregulated in many proliferating cancer cells (Jones and Morris, 2016), whereas MCT4 inhibition has been shown to prevent hypoxic response, cell proliferation and tumor progression (Voss et al., 2017). This evidence concerns the gene SLC16A3 and neoplasm.