ANGII plays an essential role in various physiological functions, and overactivation of the RAS is associated with several pathological conditions such as essential hypertension and insulin resistance (Henriksen et al., 2001; Ran et al., 2004; Olivares-Reyes et al., 2009; Chen et al., 2010; Luther and Brown, 2011; Deji et al., 2012). This evidence concerns the gene AGT and essential hypertension.