On the other hand, boosting BDNF/TrkB signaling was shown to ameliorate synaptic function and cognitive decline in mouse models of AD (Blurton-Jones et al., 2009; Nagahara et al., 2009; Devi and Ohno, 2012; Kemppainen et al., 2012). The gene discussed is BDNF; the disease is Alzheimer disease.