BDNF and Alzheimer disease: Excitotoxicity and dysregulation of BDNF signaling are involved in several pathological processes, such as brain ischemia (Ferrer et al., 2001; Vidaurre et al., 2012; Tejeda et al., 2016), traumatic brain injury (Schober et al., 2012; Rostami et al., 2014) and neurodegenerative diseases (Porritt et al., 2005; Plotkin et al., 2014; Nguyen et al., 2016), including AD (Jerónimo-Santos et al., 2015).