GRIN2B and schizophrenia: Accordingly, numerous studies have suggested that NR2B, rather than NR2A, is involved in schizophrenia in humans (Loftis and Janowsky, 2003; Geddes et al., 2014) and schizophrenia-like behaviors induced by NMDAR antagonists in rodents (Jiménez-Sánchez et al., 2014).