APOBEC3B and non-small cell lung carcinoma: Our analysis based on public TCGA database implicates APOBEC3B copy number variation (CNV) is amplified (gistic2 thresholded CNV > = 1 or gistic2 CNV > = 0.1) in 29.9% (304 of 1017) NSCLC samples, and APOBEC3B CNV significantly positively correlates with APOBEC3B mRNA (Fig. 1c), implicating CNV amplification is one driving force for APOBEC3B mRNA upregulation during cancer evolution.